|
KMID : 0376419840080010179
|
|
Chonbuk University Medical Journal
1984 Volume.8 No. 1 p.179 ~ p.188
|
|
|
Effects of Irradiation on the Histological and Enzyme Histochemical Changes at the Microvasculature in Rabbits
|
|
|
|
|
Abstract
|
|
|
To investigate the effects of irradiation on the microvasculature, local irradiation on the ear of rabbits which were divided into 3 groups according to dosage (500, 1500, 2500 rad) was performed. Histological changes (H & E, trichrome, Val Gie39 z ani reticulin stain) and enzyme histochemical changes (acid phosphatase, alkaline phosphatase, nonspecific esterase stain) were examined at 12 hours, 24 hours, 5 days, 10 days, 3 weeks and 4 weeks, respectively.
The results were as follows:
1. The inflammafy reactions such as vasodilatation, edema, margination and migration of the inflammatory cells were most remarkable at 12 and 24 hours. Five hundred rad-irradiated group showed t he ab ove reaction and it. was progressively disappeared after 5 days, but 2, 500 rad-irradiated group showed persistent inflmmatory reaction after 10 days.
2. The nuclear enlargement of endothelial cells was observed at 12 hours and it was returned to normal after 5 to 10 days. This reaction was not changed by amount of irradiation.
3. Five hundred rad-irradiated group showed arteriovenous anastomosis at 5 days and 1, 500 and 2, 500 rad eradiated group showed it at 12 hours.
4. The hypertrophy of connective tissue, especially collagen fiber and decrease in number of blood vessels were revealed at 10 days. This reaction was not changed by amount of irradiation.
5. On enzyme histochemical changes, acid phosphatase and nonspecific esterase activities were demonstrated at inflammatory cells, skin and hair follicles and alkaline phosphatase activities were demonstrated at inflammatory cells and hair follicles.
In endothelial cells, enzyme activities were not significant, and these reactions were not changed by amount of irradiation.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|